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KMID : 0351619670080020365
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Kyungpook Medical Journal
1967 Volume.8 No. 2 p.365 ~ p.379
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Effect of Placenta Extract on Repair Process
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Abstract
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Various tissue extracts from homogenized placenta, liver, kidney:, heart tissue and t~stosterone were applied over the aseptic incised wounds of the abdominal wall of female albino rats to study their effects on the wound healing, and their effects were studied hi~topathologically´ and also with tensile strength test.
Each extract of placenta and liver was injected into the intracutaneous tiasues of normal rabbits to observe the local inflammatory and reparative responses histopa-~hlogically.
The results a: a summarized as follows:
1. In the group with placenta extract over the abdominal wound of the albino rats, the measurement of tensile strength 7 da~rs after the application exhibited 43.3 %increase as compared wiih both the control and testosterone ;roap~, 12.4% increase compared with both liver and kianey extract groups, and 14.7 % increase comparedwith. heart extract group.
2. After the various tissue extracts were applied. over the wound or injected into the intracutaneous tissue, the inflammatory reaction appeared first and then the reparative responses later.
3. Tile granulation tissue and the formation of fibra.tic tissue were accelerated after the injection of the placenta extract into the intradermal tissue.
4. During 7 or 8 days after the placenta extract was applied over the wound or injected into the intracutaneous tissue, the wound healing process vas apparently accelerated but was then followed by delayed maturation of the scars.
5. The inflammation-inducing ability of the liver extracts was stronger than that of the placenta extracts whereas the growth promoting ability was the opposite.
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